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macrophage fas-induced apoptosis (mafia) mice  (Jackson Laboratory)

 
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    Jackson Laboratory macrophage fas-induced apoptosis (mafia) mice
    Macrophage Fas Induced Apoptosis (Mafia) Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/macrophage fas-induced apoptosis (mafia) mice/product/Jackson Laboratory
    Average 90 stars, based on 1 article reviews
    macrophage fas-induced apoptosis (mafia) mice - by Bioz Stars, 2026-03
    90/100 stars

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    Representative images of SOX10 and C5aR1 (#orb393229, rabbit polyclonal, Biorbyt Ltd, 1:100) co-expression in sciatic ( a ) and trigeminal ( b ) nerve tissue from C57BL/6 J female (B6) mice, ( n = 4 independent experiments) (Scale bar, 50 μm). (c) C5aR1 mRNA relative expression in primary mouse and human Schwann cells ( n = 3 independent experiments). d Schematic representation of AAV-(loxP-shRNA)- C5aR1 vector pre- and post-Cre switch. e Representative images and cumulative data (Rcoloc) of SOX10 and C5aR1 (#orb393229, rabbit polyclonal, Biorbyt Ltd, 1:100) co-expression in sciatic and trigeminal nerve tissue in Plp -AAV- C5aR1 and Control mice ( n = 4 independent experiments) (Scale bar, 50 μm). f Time-dependent periorbital (PMA), hind paw (HMA), and abdominal (AMA) mechanical allodynia in endometriotic (endo) or Sham Plp -AAV- C5aR1 and Control mice. ( n = 8 mice per group). g Representative images and cumulative data of F4/80 + cells in sciatic and trigeminal nerve tissue in endo or Sham Plp -AAV- C5aR1 and Control mice. ( n = 4 independent experiments) (Scale bar, 50 μm, dashed lines, perineurium ). h Representative images and cumulative data of transmigrated <t>macrophages</t> after stimulation of human and mouse Schwann cells with C5a or vehicle (Veh) and in the presence of DF2593A (DF25) or Veh ( n = 6 independent experiments). Data are mean ± s.e.m. c , Student’s t-test, f , 2-way, g, h 1-way ANOVA, Bonferroni correction; **** P < 0.0001 vs. Sham/Control, #### P < 0.0001 vs. Endo/Control. Source data are provided as a Source Data file.
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    macrophage fas-induced apoptosis (mafia) transgenic mice  (Jackson Laboratory)
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    Representative images of SOX10 and C5aR1 (#orb393229, rabbit polyclonal, Biorbyt Ltd, 1:100) co-expression in sciatic ( a ) and trigeminal ( b ) nerve tissue from C57BL/6 J female (B6) mice, ( n = 4 independent experiments) (Scale bar, 50 μm). (c) C5aR1 mRNA relative expression in primary mouse and human Schwann cells ( n = 3 independent experiments). d Schematic representation of AAV-(loxP-shRNA)- C5aR1 vector pre- and post-Cre switch. e Representative images and cumulative data (Rcoloc) of SOX10 and C5aR1 (#orb393229, rabbit polyclonal, Biorbyt Ltd, 1:100) co-expression in sciatic and trigeminal nerve tissue in Plp -AAV- C5aR1 and Control mice ( n = 4 independent experiments) (Scale bar, 50 μm). f Time-dependent periorbital (PMA), hind paw (HMA), and abdominal (AMA) mechanical allodynia in endometriotic (endo) or Sham Plp -AAV- C5aR1 and Control mice. ( n = 8 mice per group). g Representative images and cumulative data of F4/80 + cells in sciatic and trigeminal nerve tissue in endo or Sham Plp -AAV- C5aR1 and Control mice. ( n = 4 independent experiments) (Scale bar, 50 μm, dashed lines, perineurium ). h Representative images and cumulative data of transmigrated <t>macrophages</t> after stimulation of human and mouse Schwann cells with C5a or vehicle (Veh) and in the presence of DF2593A (DF25) or Veh ( n = 6 independent experiments). Data are mean ± s.e.m. c , Student’s t-test, f , 2-way, g, h 1-way ANOVA, Bonferroni correction; **** P < 0.0001 vs. Sham/Control, #### P < 0.0001 vs. Endo/Control. Source data are provided as a Source Data file.
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    Representative images of SOX10 and C5aR1 (#orb393229, rabbit polyclonal, Biorbyt Ltd, 1:100) co-expression in sciatic ( a ) and trigeminal ( b ) nerve tissue from C57BL/6 J female (B6) mice, ( n = 4 independent experiments) (Scale bar, 50 μm). (c) C5aR1 mRNA relative expression in primary mouse and human Schwann cells ( n = 3 independent experiments). d Schematic representation of AAV-(loxP-shRNA)- C5aR1 vector pre- and post-Cre switch. e Representative images and cumulative data (Rcoloc) of SOX10 and C5aR1 (#orb393229, rabbit polyclonal, Biorbyt Ltd, 1:100) co-expression in sciatic and trigeminal nerve tissue in Plp -AAV- C5aR1 and Control mice ( n = 4 independent experiments) (Scale bar, 50 μm). f Time-dependent periorbital (PMA), hind paw (HMA), and abdominal (AMA) mechanical allodynia in endometriotic (endo) or Sham Plp -AAV- C5aR1 and Control mice. ( n = 8 mice per group). g Representative images and cumulative data of F4/80 + cells in sciatic and trigeminal nerve tissue in endo or Sham Plp -AAV- C5aR1 and Control mice. ( n = 4 independent experiments) (Scale bar, 50 μm, dashed lines, perineurium ). h Representative images and cumulative data of transmigrated macrophages after stimulation of human and mouse Schwann cells with C5a or vehicle (Veh) and in the presence of DF2593A (DF25) or Veh ( n = 6 independent experiments). Data are mean ± s.e.m. c , Student’s t-test, f , 2-way, g, h 1-way ANOVA, Bonferroni correction; **** P < 0.0001 vs. Sham/Control, #### P < 0.0001 vs. Endo/Control. Source data are provided as a Source Data file.

    Journal: Nature Communications

    Article Title: Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis

    doi: 10.1038/s41467-024-54486-6

    Figure Lengend Snippet: Representative images of SOX10 and C5aR1 (#orb393229, rabbit polyclonal, Biorbyt Ltd, 1:100) co-expression in sciatic ( a ) and trigeminal ( b ) nerve tissue from C57BL/6 J female (B6) mice, ( n = 4 independent experiments) (Scale bar, 50 μm). (c) C5aR1 mRNA relative expression in primary mouse and human Schwann cells ( n = 3 independent experiments). d Schematic representation of AAV-(loxP-shRNA)- C5aR1 vector pre- and post-Cre switch. e Representative images and cumulative data (Rcoloc) of SOX10 and C5aR1 (#orb393229, rabbit polyclonal, Biorbyt Ltd, 1:100) co-expression in sciatic and trigeminal nerve tissue in Plp -AAV- C5aR1 and Control mice ( n = 4 independent experiments) (Scale bar, 50 μm). f Time-dependent periorbital (PMA), hind paw (HMA), and abdominal (AMA) mechanical allodynia in endometriotic (endo) or Sham Plp -AAV- C5aR1 and Control mice. ( n = 8 mice per group). g Representative images and cumulative data of F4/80 + cells in sciatic and trigeminal nerve tissue in endo or Sham Plp -AAV- C5aR1 and Control mice. ( n = 4 independent experiments) (Scale bar, 50 μm, dashed lines, perineurium ). h Representative images and cumulative data of transmigrated macrophages after stimulation of human and mouse Schwann cells with C5a or vehicle (Veh) and in the presence of DF2593A (DF25) or Veh ( n = 6 independent experiments). Data are mean ± s.e.m. c , Student’s t-test, f , 2-way, g, h 1-way ANOVA, Bonferroni correction; **** P < 0.0001 vs. Sham/Control, #### P < 0.0001 vs. Endo/Control. Source data are provided as a Source Data file.

    Article Snippet: To evaluate the involvement of macrophages, transgenic Macrophage Fas-Induced Apoptosis (MaFIA) mice (C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J, stock No: 005070, RRID:IMSR_JAX:005070, Jackson Laboratories) were used.

    Techniques: Expressing, shRNA, Plasmid Preparation, Control